Double-homozygosity for factor V Leiden and the prothrombin gene G20210A variant in a young patient with idiopathic venous thrombosis.

1. Fanelli M, Minucci S, Gelmetti V, Nervi C, Gambacorti-Passerini C, Pelicci PG: Constitutive degradation of PML/RARa through the proteasome pathway mediates retinoic acid resistance. Blood 93:1477, 1999 2. Bonn D: Targeting protein breakdown to treat cancer. Molec Med Today 5:48, 1999 3. Delic J, Masdehors P, Omura S, Cosset JM, Dumont J, Binet JL, Magdelenat H: The proteasome inhibitor lactacystin induces apoptosis and sensitizes chemoand radioresistant human chronic lymphocytic leukaemia lymphocytes to TNF-alpha-initiated apoptosis. Br J Cancer 77:1103, 1998 4. Wojcik C, Stoklosa T, Giermasz A, Golab J, Zagozdzon R, Kawiak J, Wilk S, Komar A, Kaca A, Malejczyk J, Jakobisiak M: Apoptosis induced in L1210 leukemia cells by an inhibitor of the chymotrypsin-like activity of the proteasome. Apoptosis 2:455, 1997 5. Lotan R, Ong DE, Chytil F: Comparison of the level of cellular retinoid-binding proteins and susceptibility to retinoid-induced growthinhibition of various neoplastic cell lines. J Nat Cancer Inst 64:1259, 1980 6. Moqattash S, Lutton JD, Chiao JW, Levere RD: Abolition of L1210 clonogeneticy and G1 arrest by retinoic acid and 1,25dihydroxyvitamin D3. Cancer Lett 27:125, 1985 7. Maeda Y, Horiuchi F, Miyatake J, Sono H, Tatsumi Y, Urase F, Irimajiri K, Horiuchi A: Inhibition of growth and induction of apoptosis by all-trans retinoic acid in lymphoid cell lines transfected with the PML/RAR alpha fusion gene. Br J Haematol 93:973, 1996 8. Darzynkiewicz Z, Kapuscinski J: Acridine orange: A versatile probe of nucleic acids and other cell constituents, in Melamed MR, Lindmo T, Mendelsohn ML (eds): Flow Cytometry and Cell Sorting (2 ed). New York, NY, Wiley-Liss, 1990, p 291 9. Sadoul R, Fernandez PA, Quiquerez AL, Martinou I, Maki M, Schroter M, Becherer JD, Irmler M, Tschopp J, Martinou JC: Involvement of the proteasome in the programmed cell death of NGF-deprived sympathetic neurons. EMBO J 15:3845, 1996 10. Grimm LM, Goldberg AL, Poirier GG, Schwartz LM, Osborne BA: Proteasomes play an essential role in thymocyte apoptosis. EMBO J 15:3835, 1996